The adipokine fatty-acid binding protein 4 and cardiac remodeling
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چکیده
منابع مشابه
Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity
A critical feature of obesity is enhanced insulin secretion from pancreatic β-cells, enabling the majority of individuals to maintain glycaemic control despite adiposity and insulin resistance. Surprisingly, the factors coordinating this adaptive β-cell response with adiposity have not been delineated. Here we show that fatty acid binding protein 4 (FABP4/aP2) is an adipokine released from adip...
متن کاملLipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice.
Fatty acid-binding proteins (FABPs) facilitate the diffusion of fatty acids within cellular cytoplasm. Compared with C57Bl/6J mice maintained on a high-fat diet, adipose-FABP (A-FABP) null mice exhibit increased fat mass, decreased lipolysis, increased muscle glucose oxidation, and attenuated insulin resistance, whereas overexpression of epithelial-FABP (E-FABP) in adipose tissue results in dec...
متن کاملPlasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults
Although fatty acid binding protein 4 (FABP4) may increase risk of diabetes and exert negative cardiac inotropy, it is unknown whether plasma concentrations of FABP4 are associated with incidence of sudden cardiac death (SCD). We prospectively analyzed data on 4,560 participants of the Cardiovascular Health Study. FABP4 was measured at baseline using ELISA, and SCD events were adjudicated throu...
متن کاملRequirement for the heart-type fatty acid binding protein in cardiac fatty acid utilization.
Nonenzymatic cytosolic fatty acid binding proteins (FABPs) are abundantly expressed in many animal tissues with high rates of fatty acid metabolism. No physiological role has been demonstrated for any FABP, although these proteins have been implicated in transport of free long-chain fatty acids (LCFAs) and protection against LCFA toxicity. We report here that mice lacking heart-type FABP (H-FAB...
متن کاملAdipocytes promote cholangiocarcinoma metastasis through fatty acid binding protein 4
BACKGROUND The early occurrence regional nodal and distant metastases cholangiocarcinoma (CCA) is one of the major reasons for its poor prognosis. However, the related mechanisms are largely elusive. Recently, increasing evidences indicate that adipocytes might be involved in the proliferation, homing, migration and invasion of several malignancies. In the present study, we attempt to determine...
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ژورنال
عنوان ژورنال: Cardiovascular Diabetology
سال: 2020
ISSN: 1475-2840
DOI: 10.1186/s12933-020-01080-x